1% GHK and 1% GHK-Cu by Weight. CAIS 3 1:1 is the third generation of NIOD's multi-award-winning Copper Amino Isolate Serum. Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1. As a highly-focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all visible signs of skin aging indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin aging individually and instead forms a foundation to respect skin health.

The previous generation of CAIS contained 2% of pure GHK peptide, of which 1% branched with copper ions upon mixing, forming 1% freshly-assembled, pro-repair GHK-Cu (copper peptides) and leaving 1% free-form, pro-collagen GHK peptide, for a final ratio of 1:1. The new formula omits mixing, instead containing 1% concentration by weight of pre-assembled and fully stable GHK-Cu, alongside 1% GHK peptide. Since this formula no longer requires additional GHK peptide for copper complexation, and no other copper source is added, it carries the name CAIS 3 1:1, as a reflection of the ratio of these ingredients in formulation. CAIS 3 1:1 also includes additional collagen-supporting peptides, Tripeptide-29, Acetyl Tetrapeptide-2 and Trifluoroacetyl Tripeptide-2. Its base combines mono-dispersed, plant-derived glycogen, availability-enhancing Myristoyl Nonapeptide-3 and cross-linked hyaluronic acid.

PRO-HEALTH TECHNOLOGIES 1.0% Pure Undiluted Copper Tripeptide-1 (GHK-Cu) + 1.0% Pure Undiluted Tripeptide-1 (GHK) CAIS 3 1:1 supplies 1% pure GHK peptide (Tripeptide-1), alongside 1% Copper Tripeptide-1 (GHK-Cu). Both GHK and GHK-Cu are found in nature and originally isolated from human plasma. The concentration of these peptides in human plasma continues to drop with aging past late teenage years.The natural role of these peptides as found in the human body includes activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses, while pure GHK offers strong pro-collagen support. The 2% concentration of GHK and GHK-Cu in CAIS 3 1:1 aims to target visible signs of skin aging, including textural irregularities, uneven tone, visibly enlarged pores and a general lack of healthy radiance normally present in younger skin. In short, the skin will look healthier with visible improvements with continued use.

PRO-COLLAGEN TECHNOLOGIES 9.0% Pure Undiluted Tripeptide-29 This amino acid sequence of Glycine-Proline-Hydroxyproline supports healthy collagen and works synergistically with GHK and GHK-Cu in this function. 4.0% Complex of Acetyl Tetrapeptide-2 and Trifluroacetyl Tripeptide-2 While pro-collagen peptides broadly focus on collagen quantity, these advanced peptide technologies support healthy collagen quality and assembly for skin that looks firmer and more evenly modelled.

INTEGRITY AND DELIVERY TECHNOLOGIES 0.10% Pure Mono-Dispersed Plant Glycogen Glycogen is generally extracted from animal sources as a poly-dispersion. This advanced 100% plant-based mono-dispersed glycogen acts like hard spheres that protect the formulation peptides but break upon application for optimal dermal exposure. 9% Complex of Myristoyl Nonapeptide-3 This lipo-oligopeptide supports healthy skin renewal which is essential for maximising skin availability of technologies in this formulation and those used in any subsequent treatments. Hyaluronic Acid Crosspolymer A unique cross-linked non-animal form of hyaluronic acid helps with delivery of water and water-soluble actives through its non-equilibrium gel structure.

How to use:

Apply to face AM and PM.

Apply as the first step after cleaning before the application of thicker serums or creams.